Published December 2001
by Uppsala Universitet .
Written in English
Edition Notes
| Series | Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1095 |
| The Physical Object | |
|---|---|
| Format | Paperback |
| Number of Pages | 53 |
| ID Numbers | |
| Open Library | OL12854412M |
| ISBN 10 | 9155451578 |
| ISBN 10 | 9789155451578 |
CHS is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U GTB, by CHS and the standard antitumour drug etoposide. Etoposide induces apoptosis Author: Petra Martinsson. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U GTB, by CHS and the standard antitumour drug etoposide. Etoposide induces apoptosis . The effect of pre-exposure to μ M CHS on etoposide induced cell death was also investigated. Etoposide was added at a final concentration of μ M. CHS alone resulted in a SI of 30% in Cited by: CHS showed high antitumour activity against all eight tumour samples; the fibres from control animals had a mean net growth of 73% while CHS treatment induced a 37% mean reduction of cell.
CHS has been described as inducing an atypical form of cell death, sometimes mimicking apoptosis and sometimes resembling necrosis31 32 One study also points out that pretreatment . The role of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) and the ADP-ribosylation inhibitor 3-aminobenzamide (3-ABA) in the cytotoxicity indu Cited by: Thus, CHS only induces death in cancer cells after prolonged periods of treatment, and this effect is preceded by a sharp drop in cellular ATP levels [25,28]. Its exact mechanism of action is unclear, but previous studies indicate that CHS induces a controlled, delayed mode of cell death. The characteristics of the cell death process were investigated in vitro in Cited by:
CHS is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U GTB, by CHS and the standard . 1. The present study was aimed at elucidating the apoptosis inhibitory properties of the cyanoguanidine CHS CHS exhibits impressive cytotoxic activity in vitro and in vivo. Cited by: In a study using a panel of cell lines with different resistance patterns, the effects of CHS showed a low correlation with the activity patterns of known anticancer agents, and no sensitivity Cited by: The combination of the antitumoural pyridyl cyanoguanidine CHS and etoposide in vitro -from cytotoxic synergy to complete inhibition of apoptosis Article Nov
